BRC researcher László Nagy to continue his work studying how genetics govern the multicellularity and morphogenesis of fungi with the support of the ERC Consolidator Grant he recently won

02.02.2023

László Nagy, a senior scientific associate at the Biochemistry Institute of the ELKH Biological Research Centre (BRC) in Szeged and team leader of the institute’s Synthetic and Systems Biology Unit won a Consolidator Grant from the European Research Council (ERC) in 2022 to follow up on a Starting Grant he received from them in 2017. The focus of the project is research into how genetics govern the multicellularity and morphogenesis of fungi. Beyond the value of the basic research to be conducted, the planned experiments could bring important results in the field of fungal bioplastics, which is developing at an explosive rate today, as well as in the area of fungus cultivation.

BRC researcher László Nagy to continue his work studying how genetics govern the multicellularity and morphogenesis of fungi with the support of the ERC Consolidator Grant he recently won — László Nagy

After winning an ERC Starting Grant in 2017, László Nagy applied for and won a Consolidator Grant, which will allow the Momentum Fungal Genomics and Evolution Research Group to conduct its world-class research. The aim of the research group is to investigate how fungi have evolved and to seek answers to both basic and applied research questions related to this process. At the center of this project that has just received new funding is the issue of how genetics control multicellularity and morphogenesis in fungi. Topics related to some of the big unsolved problems in the field of biology offer exciting opportunities for those engaged in applied research and development.

In recent years, the research group has worked on setting up a laboratory of excellence with the help of both ERC and Momentum grants. Their research results are published in leading professional journals, including Nature Ecology and Evolution, and the group, considered one of the world’s leading laboratories in the field of fungal genomics, maintains intensive relationships with numerous international collaborative partners. In the course of their work, they have achieved many breakthroughs toward a better understanding of the evolution of fungi, while also building competencies and reference databases within the BRC that make it possible for the first time to answer some big open questions related to how fungi have evolved.

The group’s new research project seeks to discover what genetic changes caused multicellularity to appear, and then how it was later lost or reduced in the yeast-like and often pathogenic, so-called dimorphic fungi, as well as what laws govern the differentiation of the complex structures of fungi. The ERC support will enable the research group to delve further into methods involving functional genomics, genetics and microscopy, in addition to the already well-established technologies of high-throughput omics. Beyond the value of the basic research to be conducted, the planned experiments could bring important results in the field of fungal bioplastics, which is developing at an explosive rate today, as well as in the area of fungus cultivation. In the latter respect, the group’s work is of particular interest in Asia, where the culinary and medicinal use of fungi ‒ and therefore research on the subject as well ‒ is extremely widespread.

For László Nagy and his group, winning the ERC Consolidator Grant means more than simply a financial reward. It is also professional recognition that places them at the leading edge of research in the European Union. The support will make it possible for them to conduct world-class research in Hungary, enabling them to further strengthen their position within their field of science.

The purpose of ERC’s annual Consolidator Grant competition is to support the most outstanding European researchers in developing their research groups and fulfilling their work in their research topics. The ERC grants are the most competitive and prestigious awarded to individuals in Europe and go to support so-called “blue sky” projects that, while risky, aim to answer major research questions and promise scientific breakthroughs. Of the total of 2,222 individuals who took part in the two-round application process in 2022, 321 benefited from the 657 million euros in support allocated by the ERC for this purpose. The most important criterion for the juries in judging the applications is scientific excellence, and the maximum amount that can be awarded for each application is two million euros.

On January 31, 2023, ERC posted the list of the winners of the 2022 Consolidator Grant on its website, which this year also included, along with Nagy, Péter Makk from Hungary, an associate professor with the physics department of the Institute of Physics at the Faculty of Natural Sciences of the Budapest University of Technology and Economics (BME).