DE and ELKH researchers develope new drug compounds for cardiovascular and cancer therapies
The ELKH-DE Pharmamodul Research Team, operating at the Faculty of Pharmacy at the University of Debrecen (DE GYTK), is working on the development of new drug compounds aimed at preventing sudden cardiac death and inhibiting the proliferation of cancer cells. The researchers are synthesizing compounds, releasing hydrogen sulfide beneficial for the body, which can prevent cell death. These compounds show significant promise based on initial data. Studies presenting the current results have recently been published in the international scientific journals Chemistry ‒ A European Journal and European Journal of Pharmaceutical Sciences.
The research is of outstanding significance, as in Hungary, most people lose their lives due to cardiovascular diseases, and cancer is the second most frequent cause of death. Therefore, the researchers in Debrecen are searching for compounds that could help reduce the number of such cases.
Professor Árpád Tósaki, the leader of the eight-member research group and former head of the Department of Pharmacodynamics at the Faculty of Pharmacy (DE GYTK), reported that the researchers are modeling the ischemic condition of the heart on animals. This condition occurs when the heart does not receive enough nutrients, blood, and oxygen due to various types of cell death. They are also investigating animals with type 2 diabetes.
The primary aim of animal experiments conducted on rats is to prevent sudden cardiac death, heart attacks, and ischemia, as well as to produce compounds that can successfully fight against tumors. They hope that the new compounds will effectively destroy cancer cells while not hindering the functioning of healthy cells at all or only minimally and causing as few side effects as possible.
Árpád Tósaki also reported that they are closely collaborating with a workgroup from Mosonmagyaróvár, who conduct various examinations for the research group in their accredited laboratory.
Source: unideb.hu